Would you trade 0.1% in performance for a better debugging experience?

[Kagamin via Digitalmars-d]

I'm thinking about 3 configurations:
1. debug
2. release/conservative: assert=off, bounds checks=on, stack 
frames
3. release/optimized: bounds checks=off, no stack frames; can 
also apply additional optimizations for more speed like turning 
assert into assume.